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Article

Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.

Journal of natural products - 22 Jan 2021

Yen Shih-Chung, Chen Liang-Chieh, Huang Han-Li, Ngo Sin-Ting, Wu Yi-Wen, Lin Tony Eight, Sung Tzu-Ying, Lien Ssu-Ting, Tseng Hui-Ju, Pan Shiow-Lin, Huang Wei-Jan, Hsu Kai-Cheng

Abstract excerpt

Acute myeloid leukemia (AML) is an aggressive disease with a poor prognosis and a high degree of relapse seen in patients. Overexpression of FMS-like tyrosine kinase 3 (FLT3) is associated with up to 70% of AML patients. Wild-type FLT3 induces proliferation and inhibits apoptosis in AML cells, while uncontrolled proliferation of FLT3 kinase activity is also associated with FLT3 mutations. Therefore, inhibiting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33393294
DOI: 10.1021/acs.jnatprod.0c00589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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