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Article

ERBB2/ERBB3‑mutated S100/SOX10‑positive high‑grade uterine sarcoma-a case report on a rare entity.

Virchows Archiv : an international journal of pathology - 1 Jun 2026

Huang Xingming, He Ying, Wang Wei

Abstract excerpt

ERBB2/ERBB3‑mutated S100/SOX10‑positive uterine sarcoma is a recently described entity with distinct morphological, immunophenotypic, and molecular features, representing a subset of high-grade uterine sarcomas. This tumor is characterized by ERBB2/ERBB3 mutations or ERBB2 amplification, which leads to the overexpression or constitutive activation of HER2. The presence of HER2 amplification represents a potential...

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Topics

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Share to Erb-b2 Receptor Tyrosine Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, ErbB-3

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Source

Identifiers

PMID: 41026178
DOI: 10.1007/s00428-025-04257-5

Genes

ERBB2
SOX10
ERBB3
ATRX
BACH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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