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Article

Prevalence of Actionable Pharmacogenetic Genotype Frequencies, Cautionary Medication Use, and Polypharmacy in Community-Dwelling Older Adults.

Clinical pharmacology and therapeutics - 1 Aug 2025

Bousman Chad A, Narang Ankita, Al Bkhetan Ziad, Woods Robyn L, Orchard Suzanne G, Owen Alice J, Fravel Michelle A, Gilmartin-Thomas Julia, Ryan Joanne, Fransquet Peter D, Wolfe Rory, Yu Chenglong, McNeil John J, Lacaze Paul, Ernst Michael E

Abstract excerpt

Older adults (65 years and over) frequently manage complex medication regimens and are vulnerable to adverse drug reactions and treatment inefficacies, some of which could be preventable with pharmacogenetics (PGx)-guided prescribing. This study examined the prevalence of actionable PGx genotypes (i.e., those linked to a guideline that recommends a change to standard prescribing), the use of cautionary...

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Share to Aged, 80 and over
Share to Drug-Related Side Effects and Adverse Reactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40304392
DOI: 10.1002/cpt.3702
PMCID: PMC12272320

Genes

CYP2C19
VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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