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Clinically actionable genetic variation in patients with or at high-risk of cardiovascular diseases from the Montreal Heart Institute.

Pharmacogenomics - 1 Jan 2025

Pilon Marc-Olivier, Hindi Jessica, Oussaïd Essaïd, Amani Farida, Cyr Marie-Christyne, Mongrain Ian, Sandoval Johanna, Lemieux Perreault Louis-Philippe, Busseuil David, Tardif Jean-Claude, Leclair Grégoire, Dubé Marie-Pierre, de Denus Simon

Abstract excerpt

AIM: Pharmacogenomics enables treatments to be tailored to individual genetic profiles, optimizing efficacy while reducing adverse effects. The Clinical Pharmacogenetics Implementation Consortium (CPIC) classifies gene-drug pairs by their level of evidence. Level A and B pairs are considered actionable, indicating that prescribers should (A) or could (B) modify therapy. MATERIALS AND METHODS: This cross-sectional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41524197
DOI: 10.1080/14622416.2025.2609367
PMCID: PMC12915869

Genes

ABCG2
CYP2B6
CYP2C19
CYP2C9
CYP3A5
CYP4F2
DPYD
SLCO1B1
TPMT
UGT1A1
VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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