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Article

Exposure to environmental doses of DEHP causes phenotypes of polycystic ovary syndrome.

Toxicology - 1 Dec 2024

Wang Shuxin, Xu Ke, Du Wanting, Gao Xiao, Ma Ping, Yang Xu, Chen Mingqing

Abstract excerpt

Globally, approximately 6-20 % of women who are of reproductive age suffer from polycystic ovary syndrome (PCOS), with environmental factors believed to be significant contributors. Di-2-ethylhexyl phthalate (DEHP) is known to be an endocrine disruptor, and is also suspected of being associated with the occurrence of PCOS, but in vivo studies to verify this association are lacking. In this study, female SD rats...

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Identifiers

PMID: 39265699
DOI: 10.1016/j.tox.2024.153952

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