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Article

Biphasic (squamoid) papillary renal cell carcinoma: a distinct molecular and morphologic subtype within the PRCC spectrum.

Virchows Archiv : an international journal of pathology - 1 Sept 2026

Lu Zhichun, Zhou Yan, Fan Wei, Choksi Sanket, Sultan Lila, Katz Mark H, Wang David S, Zhao Qing, Yang Shi

Abstract excerpt

Biphasic (squamoid) papillary renal cell carcinoma (BPRCC) is a recently recognized and rare variant of renal cell carcinoma, defined by biphasic morphology and distinct immunophenotypic features. Previously considered a subtype of classic papillary RCC, its clinicopathologic and molecular characteristics remain underexplored. We analyzed ten BPRCC cases for histologic, immunophenotypic, molecular, and clinical...

Read the complete abstract on PubMed

Topics

Humans
Carcinoma, Renal Cell
Kidney Neoplasms
Male
Female
Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Immunohistochemistry

Carcinoma, Papillary

In Situ Hybridization, Fluorescence

Mutation

Phenotype

Source

Identifiers

PMID: 41006900
DOI: 10.1007/s00428-025-04248-6

Genes

AMACR
MET
ARID1A
FGFR4
GATA3
MAP2K2
NOTCH1
PAX8
PMS2
PRCC
RAD51C
RB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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