Papillary renal neoplasm with reverse polarity: a novel entity for the next WHO classification? a clinical-pathological and molecular study of 15 cases, compared to eosinophilic/oncocytic papillary renal cell carcinoma.

doi:10.1007/s00428-026-04536-9

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Article

Papillary renal neoplasm with reverse polarity: a novel entity for the next WHO classification? a clinical-pathological and molecular study of 15 cases, compared to eosinophilic/oncocytic papillary renal cell carcinoma.

Virchows Archiv : an international journal of pathology - 1 Sept 2026

Marletta Stefano, Fiorini Denise, Caliò Anna, Marcolini Lisa, Stefanizzi Lavinia, Giacometti Cinzia, Pedron Serena, Vicentini Caterina, Martignoni Guido

Abstract excerpt

Papillary renal neoplasm with reverse polarity (PRNRP) is a recently recognized renal tumor characterized by papillary architecture lined by a single layer of low-grade eosinophilic cells with apically located nuclei. In the latest WHO classification, they are not recognized as a distinct entity but rather as a morphological pattern of papillary renal cell carcinoma. To date, limited studies have compared PRNRP...

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Topics

Humans
Kidney Neoplasms
Carcinoma, Renal Cell
Female
Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Middle Aged

Carcinoma, Papillary

Aged

Immunohistochemistry

World Health Organization

Adult

Mutation

Eosinophils

Eosinophilia

Source

Open in PubMed Open full text

Identifiers

PMID: 42053817
DOI: 10.1007/s00428-026-04536-9
PMCID: PMC13582226

Genes

GATA3
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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