Pervasive sex-dependent effects in the genetic architecture of starvation resistance in Drosophila melanogaster.

doi:10.1126/sciadv.adt3560

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Pervasive sex-dependent effects in the genetic architecture of starvation resistance in Drosophila melanogaster.

Science advances - 26 Sept 2025

Chen Junhao, Liu Chenlu, Li Weixuan, Clark Andrew G, Wang Zhijuan, Lu Jian

Abstract excerpt

Genetic variants can have sex-specific, sex-biased, or sexually antagonistic fitness effects, yet their roles in fitness-related traits remain unclear. Using pooled phenotype sorting and sequencing of male Drosophila melanogaster from natural populations, we identified starvation resistance-associated variants, many in regulatory regions or altering protein sequences. RNA interference experiments showed that...

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Drosophila melanogaster
Drosophila Proteins
Phenotype
RNA Interference
Sex Characteristics
Sex Factors
Starvation

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PMID: 41004585
DOI: 10.1126/sciadv.adt3560
PMCID: PMC12466915

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