Article

Influence of BMI-associated genetic variants and metabolic risk factors on weight loss with semaglutide: a longitudinal clinico-genomic cohort study

2024-11-02

Abstract excerpt

<h4>Background</h4> Individual weight loss response to the GLP-1 receptor agonist semaglutide varies considerably, with many possible contributing factors. Leveraging multiple clinico-genomic cohorts, we analyzed differences in weight loss trajectories according to patient characteristics, including a polygenic score (PGS) and metabolic risk factors, in semaglutide initiators with BMI ≥27 kg/m 2 . <h4>Methods</h4>...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ce9286ea-a64b-5e8d-ba7e-bb6f486330df
DOI: 10.1101/2024.10.31.24316494

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Influence of BMI-associated genetic variants and metabolic risk factors on weight loss with semaglutide: a longitudinal clinico-genomic cohort studyDOI 10.1101/2024.10.31.24316494Read

GLP1R and OCT1 variants modulate semaglutide and metformin response in type 2 diabetes.Semantic proximity Read

Impact of polygenic score for BMI on weight loss effectiveness and genome-wide association analysis.Semantic proximity Read

Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery: a multi-ancestry study in 10 960 individuals from 9 biobanksSemantic proximity Read

Exploring the clinical and genetic associations of adult weight trajectories using electronic health records in a racially diverse biobank: a phenome-wide and polygenic risk studySemantic proximity Read

Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank.Semantic proximity Read

A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN StudySemantic proximity Read

The Influence of Single Nucleotide Polymorphisms On Body Weight Trajectory After Bariatric Surgery: A Systematic Review.Semantic proximity Read

Exploring the clinical consequences and genetic aetiology of adult weight trajectoriesSemantic proximity Read

Quantifying the phenome-wide disease burden of obesity using electronic health records and genomics.Semantic proximity Read

Greater lean-body-mass decline with tirzepatide than semaglutide in routine care, revealed by body-composition digital phenotypingSemantic proximity Read

Genetic predictors of GLP1 receptor agonist weight loss and side effects.Semantic proximity Read

Precision obesity medicine: A phenotype-guided framework for pharmacologic therapy across the lifespan.Semantic proximity Read