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Article

Multiomic and electrophysiologic analyses reveal that an inherited MRC2 variant causes fibroblast dysfunction and increased atrial fibrillation susceptibility.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2025

Ho Kevin S, Keefe Joshua A, Zhao Shuai, Hulsurkar Mohit M, Jung Sung Yun, Samee Md Abul Hassan, Wehrens Xander H T

Abstract excerpt

A recent study identified a rare variant in the mannose receptor C type 2 (MRC2) gene in individuals with familial reentrant supraventricular tachycardia, a Wolff-Parkinson-White (WPW) electrocardiogram pattern, and structurally normal hearts. WPW syndrome is associated with atrial fibrillation (AF), and MRC2 was recently proposed as a protective gene for AF. We determined whether the E990G-heterozygous (het)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40983393
DOI: 10.1152/ajpheart.00452.2025
PMCID: PMC12643113

Genes

MRC2
CCN2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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