Article
Wolff-Parkinson-White syndrome: De novo variants and evidence for mutational burden in genes associated with atrial fibrillation.
American journal of medical genetics. Part A - 1 Jun 2020
Coban-Akdemir Zeynep H, Charng Wu-Lin, Azamian Mahshid, Paine Ingrid S, Punetha Jaya, Grochowski Christopher M, Gambin Tomasz, Valdes Santiago O, Cannon Bryan, Zapata Gladys, Hernandez Patricia P, Jhangiani Shalini, Doddapaneni Harsha, Hu Jianhong, Boricha Fatima, Muzny Donna M, Boerwinkle Eric, Yang Yaping, Gibbs Richard A, Posey Jennifer E, Wehrens Xander H T, Belmont John W, Kim Jeffrey J, Miyake Christina Y, Lupski James R, Lalani Seema R
Abstract excerpt
BACKGROUND: Wolff-Parkinson-White (WPW) syndrome is a relatively common arrhythmia affecting ~1-3/1,000 individuals. Mutations in PRKAG2 have been described in rare patients in association with cardiomyopathy. However, the genetic basis of WPW in individuals with a structurally normal heart remains poorly understood. Sudden death due to atrial fibrillation (AF) can also occur in these individuals. Several studies...
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