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Article

Matrin-3 forms spherical and wormlike assemblies that are modulated by RNA binding and ALS/FTD-associated mutations.

Molecular cell - 2 Oct 2025

Sprunger Macy L, Shinn Min Kyung, Talir Sabrina K, Lee Ken, Pappu Rohit V, Jackrel Meredith E

Abstract excerpt

Matrin-3 (MATR3) is an RNA-binding protein (RBP) that is associated with familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). MATR3 features two RNA recognition motifs, two zinc-finger motifs, and four intrinsically disordered regions. Here, we report that human MATR3 associates with itself to form nanoscale spherical assemblies at ultralow protein concentrations. Through...

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Identifiers

PMID: 40975059
DOI: 10.1016/j.molcel.2025.08.034
PMCID: PMC13098646

Genes

MATR3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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