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Article

Accelerated biological aging, healthy behaviors, and genetic susceptibility with incidence of stroke and its subtypes: A prospective cohort study.

Aging cell - 1 Apr 2025

Zhang Xuening, Zhao Hao, Li Zilin, Liu Xinjie, Zhang Yurong, Yang Ning, Zhang Tongchao, Yang Xiaorong, Lu Ming

Abstract excerpt

Stroke risk increases with chronological age, but the relationship with biological age (BA) acceleration is poorly understood. We aimed to examine the association between BA acceleration and incident stroke and its subtypes, explore the modifying effects on genetic susceptibility, and assess how BA acceleration mediates the effect of behavior score. We studied 253,932 UK Biobank participants and computed two BA...

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PMID: 39632479
DOI: 10.1111/acel.14427
PMCID: PMC11984664

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