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Article

Somatic whole exome sequencing of colorectal carcinoma in young patients from sub-Saharan Africa reveals novel insights.

The journal of pathology. Clinical research - 1 Sept 2025

Aldera Alessandro Pietro, Owusu Dennis, Biral Leonardo, Pillay Komala, Boutall Adam, Dave Sandeep, Ramesar Raj

Abstract excerpt

Colorectal carcinoma (CRC) is a frequent cause of morbidity and mortality in sub-Saharan Africa. The incidence of early-onset, microsatellite stable (MSS) CRC is on the rise, and the tumour biology of these lesions is poorly categorised. Preliminary data from one centre in Nigeria found differences in the frequencies of mutations in driver genes and altered signalling pathways. We sought to investigate potential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40958358
DOI: 10.1002/2056-4538.70048
PMCID: PMC12441016

Genes

FAT4
TET2
APC
BRAF
KRAS
POLE
TP53

Variants

Provenance

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