Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights.

doi:10.1038/s41467-021-27106-w

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Article

Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights.

Nature communications - 24 Nov 2021

Alatise Olusegun Isaac, Knapp Gregory C, Sharma Avinash, Chatila Walid K, Arowolo Olukayode A, Olasehinde Olalekan, Famurewa Olusola C, Omisore Adeleye D, Komolafe Akinwumi O, Olaofe Olaejinrinde O, Katung Aba I, Ibikunle David E, Egberongbe Adedeji A, Olatoke Samuel A, Agodirin Sulaiman O, Adesiyun Olusola A, Adeyeye Ademola, Kolawole Oladapo A, Olakanmi Akinwumi O, Arora Kanika, Constable Jeremy, Shah Ronak, Basunia Azfar, Sylvester Brooke, Wu Chao, Weiser Martin R, Seier Ken, Gonen Mithat, Stadler Zsofia K, Kemel Yelena, Vakiani Efsevia, Berger Michael F, Chan Timothy A, Solit David B, Shia Jinru, Sanchez-Vega Francisco, Schultz Nikolaus, Brennan Murray, Smith J Joshua, Kingham T Peter

Abstract excerpt

Understanding the molecular and phenotypic profile of colorectal cancer (CRC) in West Africa is vital to addressing the regions rising burden of disease. Tissue from unselected Nigerian patients was analyzed with a multigene, next-generation sequencing assay. The rate of microsatellite instability is significantly higher among Nigerian CRC patients (28.1%) than patients from The Cancer Genome Atlas (TCGA, 14.2%)...

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Identifiers

PMID: 34819518
DOI: 10.1038/s41467-021-27106-w
PMCID: PMC8613248

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