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Inducing conformational preference of the membrane protein transporter EmrE through conservative mutations

21 Oct 2019

Abstract excerpt

Transporters from bacteria to humans contain inverted repeat domains thought to arise evolutionarily from the fusion of smaller membrane protein genes. Association between these domains forms the functional unit that enables transporters to adopt distinct conformations necessary for function. The small multidrug resistance (SMR) family provides an ideal system to explore the role of mutations in altering...

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PMID: 31637997
DOI: 10.7554/elife.48909

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