An equal-tempered measure of linkage disequilibrium.

Abstract excerpt

Linkage disequilibrium (LD), the association of alleles at two loci, is defined in multiple ways. Because LD measures depend on allele frequencies, it is difficult to compare LD values between populations or loci with different allele frequencies. Here, I consider a geometric interpretation of a commonly used LD measure r2 which suggests a modification that is frequency-independent in the sense that equal...

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