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An Overview of the Genetic Diversity and Epidemiological Potential of Yersinia pestis Populations in Natural Plague Foci of Kazakhstan.

Pathogens (Basel, Switzerland) - 20 May 2026

Abdirassilova Aigul, Yessimseit Duman, Kassenova Altynai, Rysbekova Altyn, Abdeliyev Beck, Zhumadilova Zauresh, Abdel Ziyat, Mussagaliyeva Raikhan, Meka-Mechenko Tatyana, Sairambekova Galiya, Begimbayeva Elmira, Nurpeisova Ainur, Sagidulin Temirkhan, Maksatova Ayaulym, Agzam Sanzhar, Nissanova Raikhan, Motin Vladimir, Reva Oleg

Abstract excerpt

This review provides a comprehensive overview of the genetic diversity and epidemiological potential of Yersinia pestis in Kazakhstan's natural plague foci, emphasizing the link between genotypic variation and outbreak capacity. Integrating historical epidemiological records with contemporary microbiological and genomic data (including PCR, VNTR/MLVA, SNP analysis, and whole-genome sequencing), we evaluate core...

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PMID: 42198677
DOI: 10.3390/pathogens15050551
PMCID: PMC13209227

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