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Cancer stem cells in focus: Deciphering the dynamic functional landscape of stemness in cancer

4 Sept 2025

Abstract excerpt

Cancer stem cells (CSCs) are central to tumour initiation, progression, and relapse, yet their dynamic and adaptive nature hampers therapeutic targeting. Once viewed as a fixed subpopulation, CSCs are now recognised as a fluid functional state that tumour cells can enter or exit, driven by intrinsic programs, epigenetic reprogramming, and microenvironmental cues. This plasticity complicates identification due to...

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PMID: 40912376
DOI: 10.1016/j.bbcan.2025.189440

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