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Article

Recurrent FGFR2 and PIK3CA Mutations in Sialoblastoma.

Head and neck pathology - 4 Sept 2025

Koo Selene C, Ma Jingqun, Tran Quynh T, Alaggio Rita, Stracuzzi Alessandra, Chou Pauline M, Wilkins Benjamin J, Orr Brent A, Malik Faizan

Abstract excerpt

PURPOSE: Sialoblastoma is an extremely rare low-grade malignant salivary gland neoplasm that presents at birth or early infancy and has heterogeneous clinical behavior. Due to its rarity, the molecular landscape remains incompletely characterized. We aimed to expand the current understanding of the genetic alterations in sialoblastoma through comprehensive molecular analysis. METHODS: Five sialoblastoma cases...

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Source

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Identifiers

PMID: 40906279
DOI: 10.1007/s12105-025-01838-3
PMCID: PMC12411370

Genes

FGFR2
CTNNB1
PIK3CA

Variants

Provenance

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