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Article

Serum metabolites and gut microbiota mediate the causal link between anxiety and nonalcoholic fatty liver disease: a Mendelian randomization analysis.

European journal of gastroenterology & hepatology - 1 Dec 2025

Wang Siyao, Liu Xinyi, He Jia, Cui Yihan, Jia Ai

Abstract excerpt

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is defined by liver fat accumulation exceeding 5% in individuals who do not consume significant amounts of alcohol. This condition can advance to more severe outcomes, including fibrosis, cirrhosis, and liver cancer. Although numerous factors contribute to the progression of NAFLD, the influence of psychological elements, especially anxiety, remains...

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PMID: 40900524
DOI: 10.1097/MEG.0000000000003043

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