A Multivariable Mendelian Randomization Analysis Disentangling The Causal Relations Between Abdominal Obesity, Non-Alcoholic Fatty Liver Disease and Cardiometabolic Diseases

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Observational studies have linked obesity and especially abdominal obesity to non-alcoholic fatty liver disease (NAFLD). These traits are also associated with type 2 diabetes (T2D) and coronary artery disease (CAD) but the causal factor(s) underlying these associations remain unexplored. Multivariable Mendelian randomization (MVMR) is a method that uses multiple...

Topics

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• Body Mass Index
• Cholesterol, HDL
• Genetic Associations and Epidemiology
• Genome-Wide Association Study
• Lipid metabolism and disorders
• Liver Disease Diagnosis and Treatment
• Mendelian Randomization Analysis
• Non-alcoholic Fatty Liver Disease

Identifiers and source

Literature Corpus work

498fdabb-cd61-5522-8cb3-0af19e274554

DOI

10.21203/rs.3.rs-1336425/v1