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Article

Gut fungi are associated with human genetic variation and disease risk.

PLoS biology - 1 Sept 2025

Van Syoc Emily P, Davenport Emily R, Bordenstein Seth R

Abstract excerpt

Human genetic determinants of the gut mycobiome remain uninvestigated despite decades of research highlighting tripartite relationships between gut bacteria, genetic background, and disease. Here, we present the first genome-wide association study on the number and types of human genetic loci influencing gut fungi relative abundance. We detect 148 fungi-associated variants (FAVs) across 7 chromosomes that...

Read the complete abstract on PubMed

Topics

Humans
Genome-Wide Association Study
Genetic Variation
Gastrointestinal Microbiome
Fungi
Genetic Predisposition to Disease
Cardiovascular Diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Quantitative Trait Loci

Cadherins

Mycobiome

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 40892706
DOI: 10.1371/journal.pbio.3003339
PMCID: PMC12404459

Genes

CDH13
ANAPC10
NAV2
PTPRC

Provenance

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