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Article

Ginsenoside Rg2 attenuates Alzheimer-like phenotypes in 3xTg-AD mice: Associations with gut microbiota and brain metabolomic profiles.

Phytomedicine : international journal of phytotherapy and phytopharmacology - 1 Oct 2026

Liu Ziqi, Li Pengcheng, Cecarini Valentina, Eleuteri Anna Maria, Nan Bo, Piao Chunhong

Abstract excerpt

BACKGROUND AND PURPOSE: Alzheimer's disease (AD) is the most common form of dementia. The microbiota-gut-brain axis represents a critical pathway bridging peripheral metabolic signals and central AD pathology. This study aimed to evaluate the effects of ginsenoside Rg2 on AD-like phenotypes in 3xTg-AD mice and to examine its associations with gut microbiota and brain metabolomic profiles. STUDY DESIGN AND...

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PMID: 42574987
DOI: 10.1016/j.phymed.2026.158678

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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