Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APOE4 genotype shapes the role of dietary fibers in cognitive health through gut microbiota changes.

Gut microbes - 1 Dec 2025

Liaquat Marrium, Le Gall Gwenaelle, Scholey Andrew, Pontifex Matthew G, Bastiaanssen Thomaz F S, Muller Michael, Minihane Anne Marie, Vauzour David

Abstract excerpt

APOE4, a key risk factor for Alzheimer's disease, influences gut microbiota and microbial metabolites (e.g. amino acids and dietary fiber (DF) derived short-chain fatty acids (SCFAs)). However, its role in modulating microbiota-driven DF metabolism and its effect on cognitive status remains unclear. This cross-sectional study (n = 170) investigates the association between APOE4 genotype, DF consumption, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E4
Share to Bacteria

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognition

Share to Cognitive Dysfunction

Share to Cross-Sectional Studies

Share to Dietary Fiber

Share to Gastrointestinal Microbiome

Source

Open in PubMed Open full text

Identifiers

PMID: 40600491
DOI: 10.1080/19490976.2025.2526133
PMCID: PMC12233883

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APOE4 genotype shapes the role of dietary fibers in cognitive health through gut microbiota changes.PMID 40600491Read ↗

Exploring the relationship between APOEε4 allele and gut microbiota composition and function in healthy adultsSemantic proximity Read ↗

Ketogenic Diet Modulates Gut Microbiota-Brain Metabolite Axis in a Sex- and Genotype-Specific Manner in APOE4 Mice.Semantic proximity Read ↗

Metagenomic association analysis of cognitive impairment in community-dwelling older adultsSemantic proximity Read ↗

Association between Apolipoprotein E genotype and the gut microbiome composition in humans and miceSemantic proximity Read ↗

Altered Gut Microbiota Mediates the Association between APOE Genotype and Amyloid-β Accumulation in Middle-Aged AdultsSemantic proximity Read ↗

Gut Microbiota and its Metabolites: Bridge of Dietary Nutrients and Alzheimer’s DiseaseSemantic proximity Read ↗

The impact of APOE genotype, age, and sex on gut microbiota in a mouse model of Alzheimer's Disease: an exploration of their interactions.Semantic proximity Read ↗

APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiologySemantic proximity Read ↗

Correlation between APOE4 gene and gut microbiota in Alzheimer’s diseaseSemantic proximity Read ↗

Dietary Pattern, Gut Microbiota, and Alzheimer’s DiseaseSemantic proximity Read ↗

Microbiota-derived short chain fatty acids promote Aβ plaque depositionSemantic proximity Read ↗

Gut Microbiota Mediates Dietary Modulation of Mild Cognitive Impairment in the Elderly: A Cross-Sectional StudySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.