Long noncoding RNA H19 promotes the acquisition of a mesenchymal-like invasive phenotype in mesothelial primary cells through an HDAC1-mediated WT1/Sp1 switch.

doi:10.1038/s41419-025-07956-8

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Long noncoding RNA H19 promotes the acquisition of a mesenchymal-like invasive phenotype in mesothelial primary cells through an HDAC1-mediated WT1/Sp1 switch.

Cell death & disease - 31 Aug 2025

Bontempi Giulio, Michetti Federica, Terri Michela, Battistelli Cecilia, Conigliaro Alice, Garbo Sabrina, Montaldo Claudia, Valente Sergio, Zwergel Clemens, Mai Antonello, Nahavandi Araghi Azadeh, Domenici Alessandro, Menè Paolo, Tripodi Marco, Strippoli Raffaele

Abstract excerpt

Peritoneal fibrosis is a pathological alteration of the peritoneal membrane occurring in pro-inflammatory conditions, including peritoneal dialysis (PD), a renal replacement therapy. Characteristic of this process is the acquisition of invasive/pro-fibrotic abilities by mesothelial cells (MCs) through induction of mesothelial to mesenchymal transition (MMT), a cell-specific form of EMT. Long noncoding (lnc) RNAs...

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Long noncoding RNA H19 promotes the acquisition of a mesenchymal-like invasive phenotype in mesothelial primary cells through an HDAC1-mediated WT1/Sp1 switch.

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