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Article

Suppression of SREBP by a transmembrane protein mutated in cardiomyopathy.

The Journal of biological chemistry - 1 Oct 2025

Takemoto Yasushi, Tserendagva Manchir, Uesugi Motonari

Abstract excerpt

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiac disorder characterized by the replacement of myocardial tissue with adipose tissue. One of the frequently mutated proteins in ARVC is TMEM43, which encodes a transmembrane protein primarily localized to the endoplasmic reticulum (ER) and nuclear membranes and stabilized by interacting with squalene synthase (SQS). However, its precise...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40885397
DOI: 10.1016/j.jbc.2025.110644
PMCID: PMC12494557

Genes

TMEM43

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Suppression of SREBP by a transmembrane protein mutated in cardiomyopathy.PMID 40885397Read ↗

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An ARVC-5 Drosophila knock-in model reveals new functions of Tmem43 in lipid homeostasis.Semantic proximity Read ↗

Functional effects of the TMEM43 Ser358Leu mutation in the pathogenesis of arrhythmogenic right ventricular cardiomyopathy.Semantic proximity Read ↗

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Newfoundland Mutation TMEM43-p.S358L Causes Impaired Cardiac Energy Metabolism and Mitochondrial Function Through Altered Protein Interaction.Semantic proximity Read ↗

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