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Article

Systems genetics analysis defines importance of TMEM43/LUMA for cardiac- and metabolic-related pathways.

Physiological genomics - 1 Jan 2022

Gu Qingqing, Xu Fuyi, Orgil Buyan-Ochir, Khuchua Zaza, Munkhsaikhan Undral, Johnson Jason N, Alberson Neely R, Pierre Joseph F, Black Dennis D, Dong Deli, Brennan Jaclyn A, Cathey Brianna M, Efimov Igor R, Towbin Jeffrey A, Purevjav Enkhsaikhan, Lu Lu

Abstract excerpt

Broad cellular functions and diseases including muscular dystrophy, arrhythmogenic right ventricular cardiomyopathy (ARVC5) and cancer are associated with transmembrane protein43 (TMEM43/LUMA). The study aimed to investigate biological roles of TMEM43 through genetic regulation, gene pathways and gene networks, candidate interacting genes, and up- or downstream regulators. Cardiac transcriptomes from 40 strains...

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Share to Arrhythmogenic Right Ventricular Dysplasia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34766515
DOI: 10.1152/physiolgenomics.00066.2021
PMCID: PMC8721901

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