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Article

TAOK2 drives opposing cilia length deficits in 16p11.2 deletion and duplication carriers

28 Aug 2025

Abstract excerpt

Deletion and duplication of the 16p11.2 genomic locus are associated with opposing changes in brain size. To determine cellular mechanisms that underlie these opposing phenotypes, we performed quantitative phosphoproteomic analyses of induced pluripotent stem cells (iPSCs)-derived neural progenitor cells (NPCs) obtained from unaffected individuals, 16p11.2 deletion, and 16p11.2 duplication carriers....

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PMID: 40882641
DOI: 10.1016/j.stemcr.2025.102608

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