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Article

Mendel randomization confirmed gastroesophageal reflux disease may increase the risk of mental disorders.

Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater - 1 Sept 2026

Wu Yang, Li Tian, Zhang Yanan, Wu Chujiang, Zheng Xiaofeng, Yu Xiaohui, Zhang Jiucong

Abstract excerpt

BACKGROUND: The potential causal relationship between gastroesophageal reflux disease (GERD) and mental disorder was analyzed using the mendelian randomization (MR) method. METHODS: Data are derived from genome-wide association study (GWAS) summary data, using gastroesophageal reflux disease (GERD) as the exposure factor. Single nucleotide polymorphisms (SNPs) significantly associated with GERD were selected as...

Read the complete abstract on PubMed

Topics

Humans
Comorbidity
Gastroesophageal Reflux
Genetic Predisposition to Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Mental Disorders

Polymorphism, Single Nucleotide

Risk Factors

Source

Identifiers

PMID: 40875158
DOI: 10.1007/s40211-025-00546-2

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