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Genotype-Specific HPV mRNA Triage Improves CIN2+ Detection Efficiency Compared to Cytology: A Population-Based Study of HPV DNA-Positive Women

30 Jul 2025

Abstract excerpt

BACKGROUND: Effective triage of women testing positive for high-risk HPV DNA is essential to reduce unnecessary colposcopies while preserving cancer prevention. Cytology, the current standard, has limited specificity and reproducibility. The genotype-specific 7-type HPV E6/E7 mRNA test (PreTect HPV-Proofer'7), targeting HPV types 16, 18, 31, 33, 45, 52, and 58, detects transcriptionally active infections and may...

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PMID: 40872259
DOI: 10.3390/pathogens14080749

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