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Genotype-Specific HPV E6/E7 mRNA Triage Improves Risk Stratification and Reduces Referrals in DNA-Positive ASC-US/LSIL: A Real-World Cohort from Nordland, Norway.

Pathogens (Basel, Switzerland) - 6 Feb 2026

Al-Shibli Khalid, Nguyen Dat Tan, Mohammed Hiba Abdul Latif, Sørbye Sveinung Wergeland

Abstract excerpt

HPV DNA-positive women with ASC-US/LSIL cytology represent a heterogeneous risk group in cervical screening and require efficient triage. We evaluated a genotype-specific 7-type HPV E6/E7 mRNA assay (PreTect HPV-Proofer 7; types 16/18/31/33/45/52/58) in a real-world quality-assurance cohort at Nordland Hospital (Bodø, Norway). Among HPV-positive women with ASC-US/LSIL reflex cytology, 225 had sufficient residual...

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Identifiers

PMID: 41754430
DOI: 10.3390/pathogens15020178
PMCID: PMC12943658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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