p16/ki67 and E6/E7 mRNA Accuracy and Prognostic Value in Triaging HPV DNA-Positive Women.

doi:10.1093/jnci/djaa105

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Article

p16/ki67 and E6/E7 mRNA Accuracy and Prognostic Value in Triaging HPV DNA-Positive Women.

Journal of the National Cancer Institute - 1 Mar 2021

Giorgi Rossi Paolo, Carozzi Francesca, Ronco Guglielmo, Allia Elena, Bisanzi Simonetta, Gillio-Tos Anna, De Marco Laura, Rizzolo Raffaella, Gustinucci Daniela, Del Mistro Annarosa, Frayle Helena, Confortini Massimo, Iossa Anna, Cesarini Elena, Bulletti Simonetta, Passamonti Basilio, Gori Silvia, Toniolo Laura, Barca Alessandra, Bonvicini Laura, Mancuso Pamela, Venturelli Francesco, Benevolo Maria

Abstract excerpt

BACKGROUND: The study presents cross-sectional accuracy of E6 and E7 (E6/E7) mRNA detection and p16/ki67 dual staining, alone or in combination with cytology and human papillomavirus (HPV)16/18 genotyping, as a triage test in HPV DNA-positive women and their impact on cervical intraepithelial neoplasia (CIN2+) overdiagnosis. METHODS: Women aged 25-64 years were recruited. HPV DNA-positive women were triaged with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32745170
DOI: 10.1093/jnci/djaa105
PMCID: PMC7936054

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