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Article

The proteomic analysis shows enrichment of RNA surveillance pathways in adult SHH and extensive metabolic reprogramming in Group 3 medulloblastomas.

Brain tumor pathology - 1 Apr 2021

Kp Manubhai, Kumar Anurag, Biswas Deeptarup, Moiyadi Aliasgar, Shetty Prakash, Gupta Tejpal, Epari Sridhar, Shirsat Neelam, Srivastava Sanjeeva

Abstract excerpt

Medulloblastoma, a common malignant brain tumor in children, comprises four molecular subgroups WNT, SHH, Group 3, and Group 4. In the present study, we performed a deep proteome-based investigation of SHH, Group 3 and Group 4 tumors. The adult SHH medulloblastomas were found to have a distinct proteomic profile. Several RNA metabolism-related pathways including mRNA splicing, 5' to 3' RNA decay, 3' to 5' RNA...

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PMID: 33438046
DOI: 10.1007/s10014-020-00391-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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