Gut-brain nexus: Mapping multimodal links to neurodegeneration at biobank scale.

doi:10.1126/sciadv.adu2937

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Article

Gut-brain nexus: Mapping multimodal links to neurodegeneration at biobank scale.

Science advances - 29 Aug 2025

Shafieinouri Mohammad, Hong Samantha, Lee Paul Suhwan, Grant Spencer M, Khani Marzieh, Dadu Anant, Schumacher Schuh Artur F, Makarious Mary B, Sandon Rodrigo, Simmonds Emily, Iwaki Hirotaka, Hill Gracelyn, Blauwendraat Cornelis, Escott-Price Valentina, Qi Yue A, Noyce Alastair J, Reyes-Palomares Armando, Leonard Hampton L, Tansey Malu, Faghri Faraz, Singleton Andrew B, Nalls Mike A, Levine Kristin S, Bandres-Ciga Sara

Abstract excerpt

Alzheimer's disease (AD) and Parkinson's disease (PD) are influenced by genetic and environmental factors. We conducted a biobank-scale study to (i) identify endocrine, nutritional, metabolic, and digestive disorders with potential causal or temporal associations with AD/PD risk before diagnosis; (ii) assess plasma biomarkers' specificity for AD/PD in the context of co-occurring gut related traits and disorders;...

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Topics

Humans
Parkinson Disease
Brain
Biological Specimen Banks

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Biomarkers

Alzheimer Disease

Male

Female

Aged

Genetic Predisposition to Disease

Neurodegenerative Diseases

Proteomics

Source

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Identifiers

PMID: 40864721
DOI: 10.1126/sciadv.adu2937
PMCID: PMC12383272

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