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Genetic architecture of hypertrophic cardiomyopathy in individuals of Chinese and United Kingdom ancestry

28 Jun 2025

Abstract excerpt

Abstract Background No studies have explored the genetic differences between the Chinese and other ethnic hypertrophic cardiomyopathy (HCM) populations. Methods This cross-sectional study included Chinese patients (n = 593) with HCM and controls (n = 491) who underwent whole-exome sequencing. Rare variants in 16 validated HCM genes were assessed and compared with a United Kingdom HCM cohort (n = 1 232) and...

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PMID: 40860236
DOI: 10.1093/pcmedi/pbaf019

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