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A Decoy Oligodeoxynucleotides Disturbing Forkhead Box O3 Mediated ctnna2 Transcriptional Repression Prevents Postoperative Neurocognitive Disorder in Mice.

CNS neuroscience & therapeutics - 1 Aug 2025

Wu Zhixin, Xie Dongkun, Zhao Jing, Zhao Jianshuai, Liu Huiqing, Xing Dong, Gu Tingting, Guo Yaru, Wang Dan, Lu Zhihong, Dong Hailong, Zhao Junlong, Deng Jiao

Abstract excerpt

BACKGROUND: Perioperative cognitive disorder (PND) affects up to 31% of surgical patients. Although clinical studies have identified a variety of risk factors, no effective prevention has been developed. From our previous cohort of PND patients, several single-nucleotide polymorphism (SNP) sites on ctnna2 were identified. The current study aims to decipher the role and regulatory mechanism of ctnna2 in the PND...

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PMID: 40859434
DOI: 10.1111/cns.70454
PMCID: PMC12380581

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CA1

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