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Article

Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank.

European heart journal - 7 Sept 2021

Ai Sizhi, Zhang Jihui, Zhao Guoan, Wang Ningjian, Li Guohua, So Hon-Cheong, Liu Yaping, Chau Steven Wai-Ho, Chen Jie, Tan Xiao, Jia Fujun, Tang Xiangdong, Shi Jie, Lu Lin, Wing Yun-Kwok

Abstract excerpt

AIMS: Observational studies have suggested strong associations between sleep duration and many cardiovascular diseases (CVDs), but causal inferences have not been confirmed. We aimed to determine the causal associations between genetically predicted sleep duration and 12 CVDs using both linear and nonlinear Mendelian randomization (MR) designs. METHODS AND RESULTS: Genetic variants associated with continuous,...

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PMID: 33822910
DOI: 10.1093/eurheartj/ehab170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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