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Article

Exploring the functional and structural impacts of high-risk nsSNPs in human BMP15 and GDF9 genes associated with premature ovarian failure: an in silico approach.

Journal of biomolecular structure & dynamics - 1 Jun 2026

Navapour Leila, Jamali Zeinab, Ghasemnejad-Berenji Hojat, Mogharrab Navid, Rezaei Arablouydareh Sahar, Sadeghpour Sonia, Jafari Abbas, Rokhsartalab Azar Pourya, Taheri-Anganeh Mortaza

Abstract excerpt

Premature ovarian failure (POF) is a complex reproductive disorder characterized by the early loss of ovarian function. Two closely related members of the transforming growth factor-β (TGF-β) superfamily, bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) have been implicated in its pathogenesis. In this study, we investigated the potential pathogenicity of 429 non-synonymous SNPs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40855915
DOI: 10.1080/07391102.2025.2549782

Genes

BMP15
GDF9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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