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Article

Flavin-deficient erythrocytes offer protection against malaria parasites.

Proceedings of the National Academy of Sciences of the United States of America - 2 Sept 2025

Hemasa Ayman, van Loon Welmoed, Fu Jonathan, Spry Christina, Jäger Julia, van Schalkwyk Donelly A, Reverberi Roberto, Ndoli Jules, Mockenhaupt Frank P, Contini Carlo, Saliba Kevin J

Abstract excerpt

Studies from the 1980s and 1990s conducted in Italy, where malaria was once endemic, hypothesized that individuals with erythrocytes deficient in flavin mononucleotide and flavin adenine dinucleotide (FAD)-collectively known as flavins-are partially protected against malaria. The condition was reported to be familial, consistent with a genetic element. This hypothesis, however, has never been tested. Using an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40854132
DOI: 10.1073/pnas.2504687122
PMCID: PMC12415205

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