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Article

Inherited glutathione reductase deficiency and Plasmodium falciparum malaria--a case study.

PloS one - 6 Oct 2009

Gallo Valentina, Schwarzer Evelin, Rahlfs Stefan, Schirmer R Heiner, van Zwieten Rob, Roos Dirk, Arese Paolo, Becker Katja

Abstract excerpt

In Plasmodium falciparum-infected red blood cells (RBCs), the flavoenzyme glutathione reductase (GR) regenerates reduced glutathione, which is essential for antioxidant defense. GR utilizes NADPH produced in the pentose phosphate shunt by glucose-6-phosphate dehydrogenase (G6PD). Thus, conditions affecting host G6PD or GR induce increased sensitivity to oxidants. Hereditary G6PD deficiency is frequent in malaria...

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Identifiers

PMID: 19806191
DOI: 10.1371/journal.pone.0007303
PMCID: PMC2751828

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