Article
Inherited glutathione reductase deficiency and Plasmodium falciparum malaria--a case study.
PloS one - 6 Oct 2009
Gallo Valentina, Schwarzer Evelin, Rahlfs Stefan, Schirmer R Heiner, van Zwieten Rob, Roos Dirk, Arese Paolo, Becker Katja
Abstract excerpt
In Plasmodium falciparum-infected red blood cells (RBCs), the flavoenzyme glutathione reductase (GR) regenerates reduced glutathione, which is essential for antioxidant defense. GR utilizes NADPH produced in the pentose phosphate shunt by glucose-6-phosphate dehydrogenase (G6PD). Thus, conditions affecting host G6PD or GR induce increased sensitivity to oxidants. Hereditary G6PD deficiency is frequent in malaria...
Topics
- Case-Control Studies
- Complement C3
- Drug Resistance
- Female
- Genetic Predisposition to Disease
- Glutathione
- Glutathione Reductase
- Homozygote
- Humans
- Immunoglobulin G
- Inhibitory Concentration 50
- Malaria, Falciparum
- Middle Aged