Article
Reduced Plasmodium vivax erythrocyte infection in PNG Duffy-negative heterozygotes.
PloS one - 28 Mar 2007
Kasehagen Laurin J, Mueller Ivo, Kiniboro Benson, Bockarie Moses J, Reeder John C, Kazura James W, Kastens Will, McNamara David T, King Charles H, Whalen Christopher C, Zimmerman Peter A
Abstract excerpt
BACKGROUND: Erythrocyte Duffy blood group negativity reaches fixation in African populations where Plasmodium vivax (Pv) is uncommon. While it is known that Duffy-negative individuals are highly resistant to Pv erythrocyte infection, little is known regarding Pv susceptibility among heterozygous...
Topics
- Adolescent
- Animals
- Carrier State
- Child
- Child, Preschool
- DNA
- Duffy Blood-Group System
- Erythrocytes
- Female
- Genetic Predisposition to Disease
- Heterozygote
- Humans
- Longitudinal Studies
- Malaria, Vivax