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Article

Second-order allosteric control as a mechanism for compensatory mutations in B-cell translocation gene 2.

Protein science : a publication of the Protein Society - 1 Sept 2025

Ose Nicholas J, Campitelli Paul, Modi Tushar, Ozkan S Banu

Abstract excerpt

The mechanism underlying the pathogenic impact of mutations within intrinsically disordered regions of proteins remains enigmatic, and the mechanisms behind compensatory responses to these perturbations lie within an even deeper veil of obscurity. This study focuses on the compensatory mechanisms of single nucleotide variants within the disordered C-terminal tail of the BTG2 protein, a crucial regulator in cell...

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Identifiers

PMID: 40852883
DOI: 10.1002/pro.70270
PMCID: PMC12375984

Genes

BTG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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