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Article

A gene-based model of fitness and its implications for genetic variation: genetic and inbreeding loads.

Genetics - 12 Nov 2025

Johri Parul, Charlesworth Brian

Abstract excerpt

In the companion paper to this, we examined the consequences for patterns of linkage disequilibrium of the "gene" model of fitness, which postulates that the effects of recessive or partially recessive deleterious mutations located at different sites within a gene fail to complement each other. Here, we examine the consequences of the gene model for the genetic and inbreeding loads, using both analytical and...

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Identifiers

PMID: 40845170
DOI: 10.1093/genetics/iyaf169
PMCID: PMC12606415

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