Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thymic epithelial cells amplify epigenetic noise to promote immune tolerance

20 Aug 2025

Abstract excerpt

Cellular plasticity is a principal feature of vertebrate adaptation, tissue repair and tumorigenesis1,2. However, the mechanisms that regulate the stability of somatic cell fates remain unclear. Here, we use the somatic plasticity of thymic epithelial cells, which facilitates the selection of a self-discriminating T cell repertoire3, as a physiological model system to show that fluctuations in background...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circadian rhythm and melatonin
Share to Dietary Effects on Health

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40836089
DOI: 10.1038/s41586-025-09424-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thymic epithelial cells amplify epigenetic noise to promote immune tolerancePMID 40836089Read ↗

AIRE in context: Leveraging chromatin plasticity to trigger ectopic gene expression*Semantic proximity Read ↗

The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription.Semantic proximity Read ↗

Aire-dependent transcripts escape Raver2-induced splice-event inclusion in the thymic epithelium.Semantic proximity Read ↗

Cross-species chromatin accessibility pinpoints HIVEP3 as a driver of thymic epithelial maturation and self-antigen expression, preventing chronic inflammationSemantic proximity Read ↗

Deconstructing the Thymic Microenvironment Through Genesis to SenescenceSemantic proximity Read ↗

ASCL1 primes medullary thymic epithelial cell programs required for central toleranceSemantic proximity Read ↗

The Thymic Orchestration Involving Aire, miRNAs, and Cell–Cell Interactions during the Induction of Central ToleranceSemantic proximity Read ↗

Thymic Epithelial CellsSemantic proximity Read ↗

Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal ClustersSemantic proximity Read ↗

Distinct mutations in the autoimmune regulator gene differentially affect transcriptional and functional properties of medullary thymic epithelial cells.Semantic proximity Read ↗

AireSemantic proximity Read ↗

Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.