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Immunopathogenesis of lethal H5N1 avian influenza virus clade 2.3.4.4b infection in macaques

18 Aug 2025

Abstract excerpt

The H5N1 avian influenza virus clade 2.3.4.4b outbreak represents a major pandemic threat for humans, with some reported cases of severe and fatal respiratory illness. A key unanswered question is the pathogenesis of severe H5N1 disease following respiratory infection. In this study, we explored mechanisms of pathogenesis of severe H5N1 disease in cynomolgus and rhesus macaques following infection with the H5N1...

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PMID: 40829590
DOI: 10.1016/j.immuni.2025.07.020

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