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The producer cell type of HSV-1 alters the proteomic contents and infectious capacity of virions

19 Aug 2025

Abstract excerpt

The cell that a virus replicates in, that is, the producer cell, can alter the macromolecular composition and infectious capacity of the virions that are produced. Herpes simplex virus type 1 (HSV-1) primarily infects keratinocytes of the epidermis or oral mucosa prior to establishing latency in neurons of the peripheral nervous system, where the virus can persist for the lifetime of the host. Many cell lines...

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PMID: 40827854
DOI: 10.1128/jvi.00829-25

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