Article

Trophoblast ferroptosis restricts SARS-CoV-2 spread in the placenta

2026-01-26

Abstract excerpt

Prenatal SARS CoV 2 infection is associated with adverse pregnancy outcomes, but placental mechanisms that restrict viral spread remain unclear. Here we show that SARS CoV2 exposure induces ferroptosis-linked iron dysregulation in the placenta as a host defense. Human placentas from early gestation SARS CoV 2 exposed pregnancies exhibited persistent viral protein expression at term, iron accumulation, disrupted lo...

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Literature Corpus work: 940eecf0-225c-5361-8608-c536a31cb541
DOI: 10.64898/2026.01.26.701742

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