Article
Genetic evaluation of pediatric pituitary adenomas and USP8-related genotype-phenotype correlations in Cushing's disease.
Pituitary - 14 Aug 2025
Zainab Rida, Kaur Sukhvir, Lack Justin, Similuk Morgan, Tandon Mayank, Ghosh Rajarshi, Seifert Bryce A, Tokita Mari, Flippo Chelsi, Yan Jia, Walkiewicz Magdalena, Chittiboina Prashant, Tatsi Christina
Abstract excerpt
PURPOSE: Pituitary adenomas (PAs) constitute a rare pediatric diagnosis and their pathogenetic mechanisms are not clearly understood. The aim of this study was to evaluate the prevalence of genetic defects in pediatric PAs through germline and tumor testing, and to describe genotype-phenotype correlations. METHODS: Fifty-four pediatric patients with PAs and available germline and/or tumor samples were studied....
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