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Article

Screening for GPR101 defects in pediatric pituitary corticotropinomas

9 Mar 2016

Abstract excerpt

Cushing disease (CD) in children is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. Germline or somatic mutations in genes such as MEN1, CDKIs, AIP, and USP8 have been identified in pediatric CD, but the genetic defects in a significant percentage of cases are still unknown. We investigated the orphan G protein-coupled receptor GPR101, a gene known to be involved in somatotropinomas,...

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PMID: 26962002
DOI: 10.1530/erc-16-0091

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